The Role of Extracellular RNA in Atherosclerotic Plaque Formation in Mice
نویسندگان
چکیده
Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen, Aachen; Dept of Biochemistry, Medical School, Justus-Liebig-University, Giessen; Core Lab for Molecular and Structural Biology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim; Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich; Rudolf Virchow Center and Institute of Clinical Biochemistry and Pathobiochemistry, University of Würzburg, Würzburg; Dept of Vascular Surgery, Klinikum rechts der Isar, Technical University, Munich, Germany; Dept of Microbiology, Kazan Federal University, Kazan, Russian Federation; Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI
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متن کاملResponse to letter regarding article "Role of extracellular RNA in atherosclerotic plaque formation in mice".
BACKGROUND Atherosclerosis and vascular remodeling after injury are driven by inflammation and mononuclear cell infiltration. Extracellular RNA (eRNA) has recently been implicated to become enriched at sites of tissue damage and to act as a proinflammatory mediator. Here, we addressed the role of eRNA in high-fat diet-induced atherosclerosis and neointima formation after injury in atheroscleros...
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Objective(s):Atherosclerosis is chronic inflammatory process triggered by oxidative stress. Oxidative stress can increase hydrogen peroxide (H2O2)level, which induce atherosclerosis through the processes such as formation of perivascular adipose tissue (PVAT), foam cells, and atherosclerotic plaque. Antioxidant is needed to control negative effects of oxidative stress. One source of antioxidant...
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OBJECTIVE The aim of this study was to analyze how an altered collagen structure affects development of atherosclerotic plaques. METHODS AND RESULTS Fibromodulin-null mice develop an abnormal collagen fibril structure. In apolipoprotein E (ApoE)-null and ApoE/fibromodulin-null mice, a shear stress-modifying carotid artery cast induced formation of atherosclerotic plaques of different phenotyp...
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تاریخ انتشار 2013